A common gene signature in tolerance to renal allograft
نویسندگان
چکیده
منابع مشابه
A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft
Patients tolerant to a kidney graft display a specific blood cell transcriptional pattern but results from five different studies were inconsistent, raising the question of relevance for future clinical application. To resolve this, we sought to identify a common gene signature, specific functional and cellular components, and discriminating biomarkers for tolerance following kidney transplanta...
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Organ transplantation requires lifelong antirejection therapy, which carries the risk of infection and cancer. A revolutionary approach is to transduce the organ graft with immunomodulatory genes to render them tolerated with no need of systemic immunosuppression. Prolonged allograft survival was achieved by adenovirus-mediated transduction of the cold-preserved kidney with sequences encoding C...
متن کاملDevelopment of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
Identifying transplant recipients in whom immunological tolerance is established or is developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed to develop reliable and reproducible in vitro assays capable of detecting tolerance in renal transplant recipients. Several biomarkers and bioassays were screened on a training set that in...
متن کاملIdentification of Common Blood Gene Signatures for the Diagnosis of Renal and Cardiac Acute Allograft Rejection
To test, whether 10 genes, diagnostic of renal allograft rejection in blood, are able to diagnose and predict cardiac allograft rejection, we analyzed 250 blood samples from heart transplant recipients with and without acute rejection (AR) and with cytomegalovirus (CMV) infection by QPCR. A QPCR-based logistic regression model was built on 5 of these 10 genes (AR threshold composite score >37% ...
متن کاملSTAT4 gene polymorphism in patients after renal allograft transplantation
INTRODUCTION STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2015
ISSN: 0085-2538
DOI: 10.1038/ki.2015.309